As a result, the designed RECS was successfully applied in the ECD-microdialysis system to in vivo/online repetitive monitoring the dynamic change of cerebral AA in the progress of the global cerebral ischemia/reperfusion events. More, the microinjection of endogenous AA and AA oxidase (AAOx) verified the reliability of the proposed RECS for in vivo/online repetitive cerebral AA detection. This proposed sensor filled the gap that no rational electrochemical sensor has been developed for the ECD-microdialysis system since its creation by the Mao group in 2005, which provided a reliable and effective method for brain chemistry research.Controlling thermal energy is one of the biggest concerns along with the progress of human civilization for thousands of years. LAQ824 concentration Current thermal comfort devices are mainly based on materials that are bulky, rigid, and heavy, largely limiting their widespread practical applications. It still remains a challenge to develop highly lightweight, flexible, and efficient electrical heaters for personal thermal management and local climate control. In this work, we present a high-performance composite infrared radiation heating fabric (IRHF), which mainly consists of two layers of poly(ethylene terephthalate) (PET) fabrics and one sandwiched layer of carbon nanofibers embedded with different inorganic nanoparticles. A copper electrode sheet was connected with the carbon nanofibers to form a conductive heating circuit. The permanent spontaneous polarization of both carbon nanofibers and infrared radiation nanoparticles can facilitate an enhanced current in the heater by creating an additional electrical field, which results in a fast electrothermal response and favorable heat preservation. The constructed IRHF could achieve an increase in the temperature to 43 °C from room temperature in 1 min under a voltage of 30 V, with an electrothermal conversion efficiency up to 78.99%. With a collection of compelling features such as good thermal stability, excellent flexibility and breathability, and high electrical conductivity and energy conversion efficiency, the fabricated sandwich-structured IRHF can open up new opportunities to develop smart heating textiles and wearable heating clothes in many fields.Peripheral neurotoxicity often occurs in patients receiving parenteral polymyxin therapy (i.e., colistin methanesulfonate or polymyxin B). The present study aimed to investigate the protective effect of curcumin on colistin-induced peripheral neurotoxicity using a murine model. Female C57BL/6 mice (n = 10 in each group) were randomly divided into the following (1) control group (saline), (2) curcumin only group (200 mg/kg/day; orally), (3) colistin only group (18 mg/kg/day; i.p.), (4) colistin (18 mg/kg/day) plus curcumin 50 mg/kg/day group, (5) colistin (18 mg/kg/day) plus curcumin 100 mg/kg/day group, (6) colistin (18 mg/kg/day) plus curcumin 200 mg/kg/day group; all mice were treated for 7 days. Orally applied curcumin was detected in the brain, cerebellum, and sciatic nerve. Co-administration of oral curcumin markedly improved colistin-induced impaired sensory and motor dysfunctions in a dose-dependent manner. Curcumin supplementation at 100 and 200 mg/kg significantly decreased lipid peroxidation and upregulated catalase (CAT) and superoxide dismutase (SOD) activities, ATP levels, and Na+/K+-ATPase activity in sciatic nerve tissue, compared to the colistin alone group. Curcumin supplementation at 200 mg/kg upregulated the levels of AKT, NGF, mTOR, Nrf2, and HO-1 mRNA and concomitantly downregulated Bax, caspases-3, and -9 mRNA; it also decreased caspase-3 and caspase-9 activity. In summary, for the first time, our study reveals that the protective effect of oral curcumin on colistin induced peripheral neurotoxicity is associated with the activation of NGF/Akt and Nrf2/HO-1 pathways and inhibition of oxidative stress. This study highlights the potential clinical application of curcumin as an oral neuroprotective agent coadministered during colistin therapy.The mainstream anaerobic ammonium oxidation (anammox) process provides strong support to the on-going paradigm shift from energy-negative to energy-neutral in wastewater treatment plants. However, the low temperature (e.g., below 15 °C) represents one of the major challenges for mainstream anammox in practice. In this study, a stable nitrogen removal rate (0.13 kg m-3 day-1), together with a high-level effluent quality ( less then 5.0 mg N L-1), was achieved in a lab-scale upflow membrane biofilm reactor (MBfR) by coupling anammox with nitrite/nitrate-dependent anaerobic methane oxidation (n-DAMO) microorganisms, at a temperature as low as 10 °C. With the temperature being progressively decreased from 25 to 10 °C, the total nitrogen removal efficiency was maintained in the range of 90-94% at a constant hydraulic retention time of 9 h. The impact of temperature on the biofilm system coupling anammox and n-DAMO reactions increased at a lower temperature range with higher Arrhenius coefficients. Additionally, 16S rRNA gene sequencing results showed that anammox bacteria, n-DAMO bacteria, and n-DAMO archaea jointly dominated the biofilm, and their respective abundances remained relatively stable when the temperature was decreased. The major reason for this temperature-tolerated performance is the overcapacity developed, which is indicated by biofilm thickness measurements and mathematical modeling. The stable performance obtained in this study shows promise for the n-DAMO application in domestic wastewater.The Lewis acidity of a metal center is influenced not only by the electronic properties of the bonded ligands but also by the bond angles, which we suggest to be important for zinc diorganyls. Molecular orbital correlation predicts that a narrower C-Zn-C bond angle of the R2Zn fragment lowers its lowest unoccupied molecular orbital (LUMO) and increases its Lewis acidity, such that it binds added ligands more strongly. Computations on Me2Zn(bipy) (bipy = 2,2'-bipyridine) yield that, for every 10° of C-Zn-C narrowing close to tetrahedral geometry, the Zn-N distance shortens by 0.027 Å (0.048 Å per 10° for the range 180-90°) and that the LUMO of the Me2Zn fragment drops by 0.24 eV. A total of 10 dialkyl zinc complexes of bipy or 4,4'-di-tert-butyl-2,2'-bipyridine are crystallographically characterized here. Structure correlations (published and new data) confirm the link between the C-Zn-C angle and Zn-N distance. Principal component analysis provides a detailed picture of the correlated distortions. Relevance for zinc fingers/zinc enzymes is discussed.