Reasonable estimates of temperature can be simulated with a limited number of tissues, although this number is higher than the number of tissues required to produce reasonable simulations of specific absorption rate. For exposures primarily in the head and thorax, six tissues may be adequate for reasonable estimates of temperature.Reasonable estimates of temperature can be simulated with a limited number of tissues, although this number is higher than the number of tissues required to produce reasonable simulations of specific absorption rate. For exposures primarily in the head and thorax, six tissues may be adequate for reasonable estimates of temperature.Wheatgrass, young germinated shoots of Triticum aestivum L., is proclaimed as antidiabetic nutraceutical by traditional medicines across the world. In this study, the effects of the wheatgrass diet in ameliorating oxidative stress (OS) induced during diabetes were investigated. Total phenolic and flavonoid contents (TPC and TFC) and in vitro antioxidant activity of wheatgrass extract were estimated at different days (5, 7, 9, 11, 13, and 15) after germination. Correlating the TPC and TFC with in vitro antioxidant activity, 9th DAG wheatgrass was found to possess maximum antioxidant potential. UHPLC-MS/MS analysis also revealed the presence of nine flavonoids. For in vivo studies, diabetes was induced by streptozotocin in Wistar rats fed with a high-fat diet. anti-PD-1 inhibitor Concomitant administration of 9th-day wheatgrass diet (200 and 400 mg/kg) for 60 days exhibited significant improvements in hyperglycemia, body weight, lipid profile, biochemical indices (AST, ALT, GSH, GPx), and restoration of tissue architectures equivalent to normal rats. Further, qRT-PCR-based expression profiling revealed a significant modulation of major antioxidant marker genes and insulin gene which substantiated that the wheatgrass diet is effective in reducing OS during diabetes. Therefore, flavonoid-rich 9th-day wheatgrass could be used as a functional food to control diabetes. PRACTICAL APPLICATIONS The present research supported that wheatgrass protects against oxidative stress and therefore could be utilized to ameliorate diabetes. The findings may contribute to the development and formulation of wheatgrass-based functional food or dietary supplement for diabetes by nutraceutical industries. Histidine-tryptophan-ketoglutarate (HTK) cardioplegia for myocardial protection obviates the need for maintenance cardioplegia doses, and thus allows for greater focus on procedure accuracy. The aim of this meta-analysis is to evaluate the safety and efficacy of HTK versus multidose cardioplegias during cardiac surgery in an adult population. Electronic searches were performed using PubMed, Science Direct, and Google Scholar databases. The key search terms included HTK cardioplegia AND cardiac surgery AND adult. This was followed by a meta-analysis investigating cardiopulmonary bypass (CPB) duration, cross-clamp duration, spontaneous defibrillation, inotropic support, mortality, atrial fibrillation, creatine kinase muscle brain band (CK-MB) and troponin I (TnI). Seven randomized controlled trials (n = 804) were analyzed. Spontaneous defibrillation following aortic cross-clamp removal significantly favored HTK (odds ratio [OR], 2.809; 95% confidence interval [CI], 1.574 to 5.012; I  = 0%; p < .01). mortality. Hypertrophic obstructive cardiomyopathy (HOCM) is one of the most common genetic cardiac diseases and encompasses an array of clinical presentations. Little is known about the impact of genetic background on outcomes after septal myectomy (SM). The aim of this study was to evaluate the effect of specific genetic mutations on midterm outcomes in adults undergoing SM for HOCM. From 2003 to 2020, a total of 59 patients (male = 66%, mean age = 52 ± 13) underwent SM after a preoperative genetic test. Patients were divided into two groups according to their test result (positive or negative). Preoperative echocardiograms were examined to identify phenotypical characteristics of each mutation. A total of thirty-one patients (53%) had a positive genetic test. MYBPC3 was the most common mutation (15/31 patients). Four different phenotypes were identified on preoperative echocardiograms. Overall, Type 1 phenotype was the most common (37% of the cohort). Type 3 was found exclusively in patients with a positive genetic test. Following SM, none of the patients required a redo myectomy or septal ablation. At 10 years, the survival was 97 ± 3% and 100% in patients with a positive and negative genetic test (p = .33), respectively. Although our results suggest that the multiple gene mutations present with different characteristics and phenotypes, midterm results of SM appear to be good regardless of genetic mutation presence.Although our results suggest that the multiple gene mutations present with different characteristics and phenotypes, midterm results of SM appear to be good regardless of genetic mutation presence. Left ventricular aneurysms (LVA) are serious complications of myocardial infarction, being divided into true and false type. The false one-pseudoaneurysm (PA), is a life-threatening condition that requires urgent treatment due to the high risk of rupture. An 84-year-old female presented with progressive heart failure symptoms. Investigation showed a small true LVA and a large PA. Open surgical repair was ruled out as Euroscore and Society of Thoracic Surgeons (STS) score were 42.80% and 39.97%, respectively. After discussion at our Heart Team meeting, percutaneous approach was found to be the best option. Guided by transesophageal echocardiography, we used an interventricular septal defect occluder to close the gap between the LV and the PA. Control ventriculography showed full closure of the gap, with no residual flow to the PA cavity. The patient was discharged from the hospital on the fifth postoperative day and has remained asymptomatic since then. Percutaneous approach proved to be a safe and effective modality to treat LV PA. The device implanted achieved the goal of blocking blood flow through the communication between LV and the PA.Percutaneous approach proved to be a safe and effective modality to treat LV PA. The device implanted achieved the goal of blocking blood flow through the communication between LV and the PA.