Repetitive elements occupied a substantial portion of the assembly (62.5%), the highest of the figures reported among crustacean species. The availability of this high-quality genome assembly enabled the identification of genes associated with rapid growth in the black tiger shrimp through the comparison of hepatopancreas transcriptome of slow-growing and fast-growing shrimps. The results highlighted several growth-associated genes. Our high-quality genome assembly provides an invaluable resource for genetic improvement and breeding penaeid shrimp in aquaculture. BAY2416964 The availability of P. monodon genome enables analyses of ecological impact, environment adaptation and evolution, as well as the role of the genome to protect the ecological resources by promoting sustainable shrimp farming.Psychological interventions often use guided discovery and other techniques for diagnostic exploration and intervention planning. This way, memories may arise in the person, which may be true or false. False memories of earlier events can be harmful and result in real suffering, similar to actual traumatic memories. Based on cognitive psychological and psycho-traumatological findings, there is pronounced dissent in the academic disciplines regarding the conceptualization, relevance and research of false memories. This review contributes to the basic question of how often false beliefs and false memories may be induced within the frame of different interactional techniques. A systematic review has been conducted of 59 articles from (quasi-)experimental studies and two qualitative sources from 30 data bases. Three main methods of memory induction provide the basis for reporting imagination inflation, false feedback, and memory implantation. Due to the conceptual and methodological diversity of the studies, the results appear to be heterogeneous. Free and guided imagery, as well as suggestive statements, could induce false beliefs or false memories in, on average, 20%-50% of the participants who underwent experimental manipulation concerning false past events. A false belief induction may occur after dream interpretation or hypnosis in more than 50% of participants. Personalized suggestion is more effective in inducing memory than the general plausibility of the suggested events. Further research questions are which therapeutic actions seem appropriate in cases of harmful false memories. This depends not only on whether there are veridical elements in the false memory but also on the quality and meaning of the memory for the person's life and ability to cope with burdens.While halide perovskites (HPs) have achieved enormous success in the field of optoelectronic applications, much attention has been recently drawn to the unique polarization sensitivity of HPs, either intrinsic or extrinsic, which makes HPs a potential candidate for innovative applications in directly polarized luminescence and detection. Herein, the research status in the field of polarization-sensitive HPs, including linear polarization and circular polarization, is comprehensively summarized. To evaluate the effectiveness of HPs in generating and detecting linearly or circularly polarized light, the principles and characterization methods of polarized luminescence and detection are introduced. Sequentially, the state-of-the-art development of the strategies that induce the linear or circular polarization characteristics of HPs is systematically reviewed, based on which the application of polarization-sensitive HPs in the field of polarization luminescence and detection are summarized. Moreover, the current challenges and opportunities are discussed, and prospects of the future development in this promising field are outlined. Three-dimensional (3D) whole-brain vessel wall imaging (VWI) has demonstrated exquisite image quality for delineating intracranial atherosclerotic disease (ICAD) and reliability for quantifying normal vessel dimensions. However, its reliability in quantifying plaque morphology remains unknown. To evaluate the plaque morphologic quantification reliability of 3D whole-brain VWI in patients via comparison with 3D targeted VWI and 2D turbo spin-echo (TSE). Prospective. Thirty-three patients with symptomatic ICAD. A 3D and 2D TSE acquired at 3.0 T. Each participant underwent two VWI sessions with an interval of 7-10 days. Three readers identified in consensus all the plaques on both whole-brain and targeted 3D VWI. Their lumen and vessel wall area and volume, plaque burden, percent stenosis, and vessel wall remodeling were measured for by two independent readers. At each culprit plaque determined by a radiologist, the lumen and vessel wall area, plaque burden, plaque-to-wall contrast ratio (CR), and plic quantification of ICAD and outperforms 3D targeted VWI. 2 TECHNICAL EFFICACY STAGE 2.2 TECHNICAL EFFICACY STAGE 2.Infection with SARS-CoV-2 elicits robust antibody responses in some patients, with a majority of the response directed at the receptor binding domain (RBD) of the spike surface glycoprotein. Remarkably, many patient-derived antibodies that potently inhibit viral infection harbor few to no mutations from the germline, suggesting that naïve antibody libraries are a viable means for discovery of novel SARS-CoV-2 neutralizing antibodies. Here, we used a yeast surface-display library of human naïve antibodies to isolate and characterize three novel neutralizing antibodies that target the RBD one that blocks interaction with angiotensin-converting enzyme 2 (ACE2), the human receptor for SARS-CoV-2, and two that target other epitopes on the RBD. These three antibodies neutralized SARS-CoV-2 spike-pseudotyped lentivirus with IC50 values as low as 60 ng/ml in vitro. Using a biolayer interferometry-based binding competition assay, we determined that these antibodies have distinct but overlapping epitopes with antibodies elicited during natural COVID-19 infection. Taken together, these analyses highlight how in vitro selection of naïve antibodies can mimic the humoral response in vivo, yielding neutralizing antibodies and various epitopes that can be effectively targeted on the SARS-CoV-2 RBD.