Lateral lumbar interbody fusion (LLIF) is a widely used technique for anterior fusion. However, posterior decompression or instrumentation often requires repositioning the patient, which increases operative time. This video describes the prone LLIF as a modification of the standard surgical technique. The prone LLIF facilitates simultaneous decompression and fusion, which avoids the need for repositioning the patient, increasing operative efficiency. Positioning, fluoroscopic considerations, and operative nuances involved in performing the LLIF in the prone position are described, and an illustrative case is presented. The patient provided informed consent for the procedure and videography. LLIF in the prone position can decrease operative time and increase operative efficiency. The prone position is a viable alternative to the conventional lateral decubitus position. Video used with permission from Barrow Neurological Institute, Phoenix, Arizona.Naturally occurring protein switches have been repurposed for the development of biosensors and reporters for cellular and clinical applications1. However, the number of such switches is limited, and reengineering them is challenging. Here we show that a general class of protein-based biosensors can be created by inverting the flow of information through de novo designed protein switches in which the binding of a peptide key triggers biological outputs of interest2. The designed sensors are modular molecular devices with a closed dark state and an open luminescent state; analyte binding drives the switch from the closed to the open state. Because the sensor is based on the thermodynamic coupling of analyte binding to sensor activation, only one target binding domain is required, which simplifies sensor design and allows direct readout in solution. We create biosensors that can sensitively detect the anti-apoptosis protein BCL-2, the IgG1 Fc domain, the HER2 receptor, and Botulinum neurotoxin B, as well as biosensors for cardiac troponin I and an anti-hepatitis B virus antibody with the high sensitivity required to detect these molecules clinically. Given the need for diagnostic tools to track the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)3, we used the approach to design sensors for the SARS-CoV-2 spike protein and antibodies against the membrane and nucleocapsid proteins. The former, which incorporates a de novo designed spike receptor binding domain (RBD) binder4, has a limit of detection of 15 pM and a luminescence signal 50-fold higher than the background level. The modularity and sensitivity of the platform should enable the rapid construction of sensors for a wide range of analytes, and highlights the power of de novo protein design to create multi-state protein systems with new and useful functions.How did the Japanese establish a medical welfare system? In answering this question, historians of modern Japan have accentuated the assertive role of state bureaucrats, especially from those of the Home Ministry (naimushō). Historians of Japanese medicine also emphasized the role of the state. William Johnston, in his pioneering work on tuberculosis in Japan, explored the rise of a hygiene administration on this disease as a state enterprise. In the medical history of Japan, scholars highlighted the significance of the wartime period in the birth of this system. The emphasis on the Japanese wartime state is justified. The Japanese government managed to establish a national health insurance in 1935, while the United States government has not been able to establish a medical insurance for every citizen to this day. However, these scholars have not explored how welfare benefits were distributed to members of Japanese society. This article seeks to fill this historiographical gap by looking at the Student Healths in how to manage living as mental-worker "gentlemen," in coping with tuberculosis, venereal diseases, and neurotic breakdown. Also, they produced statistics about the health condition of Tōdai students, which immediately stimulated further investment in the facilities of Tōdai authorities for the center. Based on statistical data, Tōdai authorities developed a hygiene campaign against tuberculosis so that students could take advantage the of state-of-the-art treatments inexpensively. As such, Tōdai students became among the biggest beneficiaries of this process. In other words, the Student Health Center had a dual significance at Tōdai a medicare institution as well as part of privileged campus culture. Tōdai was a symbolic locus that reveals the uneven diffusion of medical welfare benefits in Japanese society. Through the lens of this facility, this article seeks to explore the paradox of welfare in meritocracy that contributed to the formation of the elite class in modern Japan.This study examines the life and research of Miki Sakae, a historian of Korean medicine, to explore the relationship between the study of medical history in Korea and Japan. Miki's investigation and research on old medical books conducted in colonial Korea became the starting point and foundation for the study of the history of Korean medicine. However, due to the peculiarity of being 'a Japanese who studied the history of Korean medicine,' there was no sufficient research on him. The gist of his research can be summed up as 'You cannot talk about Japanese and Chinese medicine without knowing the medicine in the Korean Peninsula.' This was a challenge to the Japanese medical history circles that tended to understand and interpret the history of medicine centered on their own country. Ataluren Miki defines the Korean Peninsula as an important place in East Asian medicine, based on the understanding that medicine does not spread from one center to other places, but moves and mixes with other systems of medicine like watthat is found in the history of Korean-Japanese medicine he studied, as well as the spread of infectious diseases.This paper aims to study the quarantine system established by His Corean Majesty's Customs Service (HCMCS) between 1886 to 1893, and how they responded to the influx of infectious diseases such as cholera, led by the Customs Medical Officer of Joseon. The quarantine procedure was not able to operate in the first 11 years of opening the port due to limitations within HCMCS in the P. G. von Möllendorff period. However, as the Shanghai Customs officer, H. F. Merrill concurrently served as the Chief Commissioner, Seoul, HCMCS was directly connected to Shanghai Customs which was a direct model of Chinese Maritime Customs Service. This connection caused HCMCS to build a foundation that enabled the Shanghai quarantine measures to be referred to in 1886. In alignment with this, Acting Commissioner, Jenchuan, J. F. Schoenicke developed the quarantine system of Jenchuan Customs in 1886, using the quarantine system of Shanghai Customs as reference. Jenchuan Customs introduced new concepts, such as Observation Island, Yellow Flag, Free Pratique, and also enforced quarantine inspections on vessels coming from cholera-infected areas.