for distance, and the different distances differed significantly from each other (P<.001). Both scanners provided results acceptable for the fabrication of inlays and short-span FPDs. A complete-crown scan was more accurate than an inlay scan (P<.001). Accuracy and precision were better for TR than for OC (P<.001). With maximum discrepancies of 192.5 to 294.6 μm across the dental arch, complete-arch scans cannot yet be recommended for the fabrication of long-span FPDs.With maximum discrepancies of 192.5 to 294.6 μm across the dental arch, complete-arch scans cannot yet be recommended for the fabrication of long-span FPDs. To determine whether antibiotic treatment (ABX) during platinum chemotherapy (PC) for epithelial ovarian cancer (EOC) impacts progression-free survival (PFS) and overall survival (OS). Retrospective single institution cohort study in women with newly diagnosed stage III/IV EOC (n=424) who underwent cytoreductive surgery (CRS) and PC from 2009 to 2015. ABX for >48h, including ABX against gram-positive (anti-G+ABX) bacteria were recorded. The impact of ABX on PFS and OS was assessed using univariate and multivariable Cox regression models. Of 424 eligible women, 34.7% (n=147) received ABX, with 11.3% (n=48) treated with anti-G+ABX. ABX decreased PFS (17.4 vs. 23.1months, HR 1.50, 95% CI 1.20-1.88, p<0.001) and OS (45.6 vs. 62.4months, HR 1.63, 95% CI 1.27-2.08, p<0.001) compared to no ABX. Similarly, anti-G+ABX worsened PFS (16.5 vs. 23.1months; HR 1.85, 95% CI 1.33-2.55) and OS (35.0 vs. 62.4months; HR 2.12, 95% CI 1.50-3.0, p<0.001). On multivariable analysis, all ABX and anti-G+ABX significantly worsened PFS (HR 1.31, 95% CI 1.04-1.65, p=0.02), (HR 1.50, 95% CI 1.07-2.10, p=0.02) and OS (HR 1.52, 95% CI 1.18-1.96, p=0.001), (HR 1.83, 95% CI 1.27-2.62, p=0.001) respectively. Increased Clavien Dindo score was associated with worsened PFS (1-2 - HR 1.52, 95% CI 1.14-2.03, p=0.004; 3-4 - HR 1.86, 95% CI 1.27-2.72, p=0.001) but not OS (1/2 - HR 1.35, 95% CI 0.97-1.88, p=0.08; 3/4 - HR 1.53, 95% CI 1.00-2.34, p=0.05); residual disease (p<0.05) and neoadjuvant chemotherapy (p<0.001) were associated with worse PFS and OS. In this retrospective cohort study of women with advanced EOC undergoing PC, ABX treatment was associated with decreased PFS and OS. Mechanistic studies are needed to investigate the negative impact of ABX upon PC response in EOC.In this retrospective cohort study of women with advanced EOC undergoing PC, ABX treatment was associated with decreased PFS and OS. Mechanistic studies are needed to investigate the negative impact of ABX upon PC response in EOC. The design of a videolaryngoscope blade may affect its efficacy. We classified videolaryngoscope blades as standard and non-standard shapes to compare their efficacy performing tracheal intubation in children enrolled in the Paediatric Difficult Intubation Registry. Cases entered in the Registry from March 2017 to January 2020 were analysed. We compared the success rates of initial and eventual tracheal intubation, complications, and technical difficulties between the two groups and by weight stratification. Videolaryngoscopy was used in 1313 patients. Standard and non-standard blades were used in 529 and 740 patients, respectively. Both types were used in 44 patients. In children weighing <5 kg, standard blades had significantly greater success than non-standard blades at initial (51% vs 26%, P=0.002) and eventual (81% vs 58%, P=0.002) attempts at tracheal intubation. In multivariable logistic regression analysis, standard blades had 3-fold greater odds of success at initial tracheal intubations compared with non-standard blades (adjusted odds ratio 3.0, 95% confidence interval) 1.32-6.86, P=0.0009). Standard blades had 2.6-fold greater odds of success at eventual tracheal intubation compared with non-standard blades in children weighing <5 kg (adjusted odds ratio 2.6, 95% confidence interval 1.08-6.25, P=0.033). Akt inhibitor There was no significant difference found in children weighing ≥5 kg. In infants weighing <5 kg, videolaryngoscopy with standard blades was associated with a significantly greater success rate than videolaryngoscopy with non-standard blades. Videolaryngoscopy with a standard blade is a sensible choice for tracheal intubation in children who weigh <5 kg.In infants weighing less then 5 kg, videolaryngoscopy with standard blades was associated with a significantly greater success rate than videolaryngoscopy with non-standard blades. Videolaryngoscopy with a standard blade is a sensible choice for tracheal intubation in children who weigh less then 5 kg. The majority of postoperative patients report moderate to severe pain, possibly related to opioid underdosing or overdosing during surgery. Objective guidance of opioid dosing using the Nociception Level (NOL) index, a multiparameter artificial intelligence-driven index designed to monitor nociception during surgery, may lead to a more appropriate analgesic regimen, with effects beyond surgery. We tested whether NOL-guided opioid dosing during general anaesthesia results in less postoperative pain. In this two-centre RCT, 50 patients undergoing abdominal surgery under fentanyl/sevoflurane anaesthesia were randomised to NOL-guided fentanyl dosing or standard care in which fentanyl dosing was based on haemodynamics. The primary endpoint of the study was postoperative pain assessed in the PACU. Median postoperative pain scores were 3.2 (inter-quartile range 1.3-4.3) and 4.8 (3.0-5.3) in NOL-guided and standard care groups, respectively (P=0.006). Postoperative morphine consumption (standard deviation) was 0.06 (0.07) mg kg (NOL-guided group) and 0.09 (0.09) mg kg (control group; P=0.204). During surgery, fentanyl dosing was not different between groups (NOL-guided group 6.4 [4.2] μg kg vs standard care 6.0 [2.2] μg kg , P=0.749), although the variation between patients was greater in the NOL-guided group (% coefficient of variation 66% in the NOL-guided group vs 37% in the standard care group). Despite absence of differences in fentanyl and morphine consumption during and after surgery, a 1.6-point improvement in postoperative pain scores was observed in the NOL-guided group. We attribute this to NOL-driven rather than BP- and HR-driven fentanyl dosing during anaesthesia. www.trialregister.nl under identifier NL7845.www.trialregister.nl under identifier NL7845.