047). Although the choroidal flow area increased after PRP this increase wasn't statically significant neither at 1 month nor at 6 months post-PRP (  = 0.31 and 0.23, respectively). Although OCTA parameters were not significantly affected by PRP at both short-term (1 month) and long-term (6 months) follow-ups, the FAZ area became significantly circular after PRP may be due to redistribution of blood flow in hypoperfused foveal capillary plexus.Although OCTA parameters were not significantly affected by PRP at both short-term (1 month) and long-term (6 months) follow-ups, the FAZ area became significantly circular after PRP may be due to redistribution of blood flow in hypoperfused foveal capillary plexus.Rheumatoid arthritis (RA) is an autoimmune disease, which compromises the synovial membrane resulting in chronic inflammation. Ficolins are key proteins of the lectin pathway of complement able to recognize pathogen-associated molecular patterns, apoptotic cells, and cellular debris mediating the clearance by phagocytes. High ficolin-1 and ficolin-3 levels have been observed in RA patients, however, the influence of polymorphisms in the FCN1 gene in RA is not completely established, while no study evaluated FCN3 gene polymorphisms in RA to date. We investigated the influence of FCN1 and FCN3 gene polymorphisms in the susceptibility and clinical presentation of RA. A total of 148 patients with RA and up to 160 controls from Southern Brazil were genotyped by sequence-specific PCR (PCR-SSP) for five FCN1 promoter polymorphisms (rs2989727, rs10120023, rs17039495, rs10117466, and rs10858293) and three FCN3 gene variants (rs532781899, rs28362807, and rs4494157). ML265 activator The FCN1 g.-542GG (rs10120023) genotype and g.-542G allele, were associated with increased susceptibility to RA (p = .025, OR = 1.69 [1.07-2.69]; p = .041, OR = 1.47 [1.02-2.12], respectively) and related to decreased FCN1 gene expression in whole blood (p A] polymorphism in the promoter region might contribute to RA susceptibility, probably by impacting FCN1 gene expression.In this study, a renewable biosorbent material was prepared from biological waste of widespread coastal plant, Zostera marina and employed for the biosorption of heavy metal pollution from water environment in green way. Manganese was selected as a model heavy metal to evaluate the treatment efficiency of prepared biosorbent. The batch biosorption behavior of biosorbent was investigated by the characterization, parameters evaluation, kinetic and equilibrium studies. The characterization study showed that the biosorbent has a rough surface and various binding groups for the heavy metal ions. The heavy metal concentration of 30 mg L-1, time of 60 min, pH of 6 and biosorbent amount of 10 mg were determined as the optimum biosorption conditions. The pseudo-second-order equation was found to be the best among kinetic models applied. The equilibrium data were best explained by Freundlich isotherm. The maximum biosorption efficiency based on Langmuir model was predicted as 58.426 mg g-1. Hence, the current work presents a renewable alternative biosorbent substance for the green treatment of heavy metal pollution from water medium.We reported a novel human immunodeficiency virus type 1 (HIV-1) circulating recombinant form (CRF) among four epidemiologically unlinked patients through men having sex with men in Heilongjiang Province, China. It was named CRF107_01B (this is temporary as we have not received the CRF number from HIV databases). A near full-length genome phylogenetic tree showed that CRF107_01B was generated by two CRF01_AE segments that was described as cluster 5 lineage of CRF01_AE (CRF01-5) inserted into the B (Western origin) backbone. The emergence of CRF107_01B increased the complexity of HIV-1.Tip-enhanced Raman spectroscopy (TERS) provides the sensitivity required to obtain the vibrational fingerprint of few molecules. While single molecule detection has been demonstrated in UHV experiments, the sensitivity of the technique in ambient, liquid and electrochemical conditions is still limited. In this work, we present a new strategy to increase the signal-to-noise in TERS by spatial light modulation. We iteratively optimize the phase of the excitation beam employing two different feedback mechanisms. In one optimization protocol, we monitor the spectral changes upon aberration correction and tight far-field focusing. In a second protocol, we use a phase-optimization strategy where TER spectra are directly used for feedback. Far-field tight focusing results in average signal enhancements of a factor of 3.5 in air and has no impact on TER signals obtained from solid/liquid interfaces. Using the TER spectrum as direct feedback, we obtain average signal enhancements between a factor of 2.6 in liquid and 4.3 in air. In individual cases, some bands increase by more than one order of magnitude in intensity upon spatial light modulation. Importantly, phase modulation in addition allowed the retrieval of bands that were initially not discernible from the noise. The proposed beam-modulation strategy can be easily implemented in existing TERS instruments and can help to push the detection limit of the technique in applications where the signal-to-noise level is low.The total synthesis of (+)-galbulin was achieved in 15% yield and 99% ee over eight steps from commercially available 4-veratraldehyde. The key steps include Meyer's asymmetric tandem addition to a chiral 2-oxazoline-substituted naphthalene, a Pd-catalyzed stereospecific decarboxylative γ-arylation, and a formal anti-Markovnikov hydromethylation. In addition, five unnatural lignans were synthesized using the same synthetic strategy.A surface plasmon can drive many photochemical reactions, in which effective charge separation and migration is a key. In analogy to the plasmon-semiconductor interface, the plasmon-molecule interface may also be used to improve the separation and migration of hot carriers. In this work, by using in situ Raman spectroscopy, molecular grafting on silver nanostructures is found essential for modulating the charge separation and p-aminothiophenol (PATP) oxidation reaction. When the LUMO of the grafted molecules match well the energy distribution of the plasmon-generated hot electrons, the PATP oxidation process accelerates significantly. Moreover, compared with symmetrical grafting, asymmetrical grafting is more effective in regulating the charge separation and plasmon-mediated chemical reaction. This work provides an effective strategy for deep understanding and fine modulation of plasmon-mediated photochemistry.