BACKGROUND There is increasing recognition that heart failure (HF) and cancer are conditions with a number of shared characteristics. OBJECTIVES To explore the association between tumour biomarkers and HF outcomes. METHODS In 2,079 patients of BIOSTAT-CHF cohort, we measured six established tumour biomarkers CA125, CA15-3, CA19-9, CEA, CYFRA 21-1 and AFP. RESULTS During a median follow-up of 21 months, 555 (27%) patients reached the primary end-point of all-cause mortality. CA125, CYFRA 21-1, CEA and CA19-9 levels were positively correlated with NT-proBNP quartiles (all P  less then  0.001, P for trend  less then  0.001) and were, respectively, associated with a hazard ratio of 1.17 (95% CI 1.12-1.23; P  less then  0.0001), 1.45 (95% CI 1.30-1.61; P  less then  0.0001), 1.19 (95% CI 1.09-1.30; P = 0.006) and 1.10 (95% CI 1.05-1.16; P  less then  0.001) for all-cause mortality after correction for BIOSTAT risk model (age, BUN, NT-proBNP, haemoglobin and beta blocker). All tumour biomarkers (except AFP) had significant associations with secondary end-points (composite of all-cause mortality and HF hospitalization, HF hospitalization, cardiovascular (CV) mortality and non-CV mortality). ROC curves showed the AUC of CYFRA 21-1 (0.64) had a noninferior AUC compared with NT-proBNP (0.68) for all-cause mortality (P = 0.08). A combination of CYFRA 21-1 and NT-proBNP (AUC = 0.71) improved the predictive value of the model for all-cause mortality (P = 0.0002 compared with NT-proBNP). CONCLUSIONS Several established tumour biomarkers showed independent associations with indices of severity of HF and independent prognostic value for HF outcomes. This demonstrates that pathophysiological pathways sensed by these tumour biomarkers are also dysregulated in HF. © 2020 The Authors. Journal of Internal Medicine published by John Wiley & Sons Ltd on behalf of Association for Publication of The Journal of Internal Medicine.BACKGROUND Although evidence about skeletal muscle mass loss and type 2 diabetes risk has accumulated, little information is available on the combined effect of skeletal muscle mass and abdominal obesity on type 2 diabetes. We examined whether skeletal muscle mass and abdominal obesity were synergistically associated with the prevalence of type 2 diabetes. METHODS Skeletal muscle mass and waist circumference (WC) were measured in 1515 Japanese aged 40-69 years. Serine inhibitor Relative muscle mass was calculated as percentage of total skeletal muscle mass in body weight (SMM%). Type 2 diabetes was identified as fasting serum glucose ≥7.0 mmol/L (126 mg/dL), non-fasting serum glucose ≥11.1 mmol/L (200 mg/dL), hemoglobin A1c ≥ 6.5%, and/or diabetes medication use. RESULTS The multivariable-adjusted odds ratio (OR) of prevalent diabetes from the lowest to third quartiles of SMM% compared to the highest quartile was gradually higher in both sexes. The association between a high WC and prevalent diabetes was similar. The multivariable-adjusted OR (95% confidence intervals) for the prevalence of type 2 diabetes in the low skeletal muscle mass/high WC group was 3.19 (1.78-5.71) for men and 4.46 (2.09-9.51) for women compared with the high skeletal muscle mass/low WC group. The relative excess risk due to interaction was 2.2 (0.5-3.9) in men and 2.8 (0.2-5.3) in women for an excess burden of type 2 diabetes for low skeletal muscle mass and high WC. CONCLUSIONS Low skeletal muscle mass and abdominal obesity were synergistically associated with presence of type 2 diabetes. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.AIMS AND OBJECTIVES To synthesise literature regarding PTSD among nurses. Two objectives guided this review (a) describe the prevalence of PTSD in registered nurses and (b) identify factors associated with nursing work-related PTSD. BACKGROUND Post-traumatic stress disorder (PTSD) is a psychiatric disorder that can occur from direct or indirect exposure to traumatic events. Nurses are at risk of developing PTSD due to their indirect and/or direct exposure to traumatic situations while providing care to vulnerable patient populations. DESIGN An integrative review. METHODS A literature search was conducted in PubMed and the Cumulative Index of Nursing and Allied Health Literature (CINAHL). Data extraction and quality assessment were independently performed by two reviewers. Data analysis procedures consisted of four concurrent activities data reduction, data display, data comparison and conclusion drawing and verification. Conclusions were narratively synthesised and thematically presented by review objective untrapersonal factors identified in this review may help mitigate the harmful impact of PTSD and promote nurse well-being. © 2020 John Wiley & Sons Ltd.The direct Friedel-Crafts-type coupling and dedinitrogenation reactions of vinyldiazo compounds with aromatic compounds using a metal-free strategy are described. This acid-catalyzed methodology is efficient for the formation of α-diazo-β-carbocations (vinyldiazonium ions), vinyl carbocations, and allylic or homoallylic carbocation species via vinyldiazo compounds. By choosing suitable nucleophilic reagents to selectively capture these intermediates, both trisubstituted α,β-unsaturated esters, β-indole-substituted diazo esters, and dienes are obtained in good to high yields and selectivities. Experimental insights implicate a reaction mechanism involving the selective protonation of vinyldiazo compounds and the subsequent release of dinitrogen to form vinyl cations that undergo intramolecular 1,3- and 1,4- hydride transfer processes as well as fragmentation. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.For Li-Se batteries, ether- and carbonate-based electrolytes are commonly used. However, due to the "shuttle effect" of the highly dissoluble long-chain lithium polyselenides (LPSes, Li 2 Se n , 4 ≤ n ≤ 8) in the ether electrolytes and the sluggish one-step solid-solid conversion between Se and Li 2 Se in the carbonate electrolytes, a large amount of porous carbon (> 40 wt% in the electrode) is always needed for the Se cathodes, which seriously counteracts the advantage of Se electrodes in volumetric capacity. In this work, we introduce an acetonitrile-based electrolyte to the Li-Se system, and propose a two-plateaus conversion mechanism. This new Li-Se chemistry not only avoids the "shuttle effect" but also facilitates the conversion between Se and Li 2 Se, enabling an efficient Se cathode with high Se utilization (97%) and enhanced Coulombic efficiency. Moreover, with such designed electrolyte, a highly compact Se electrode (2.35 g Se cm -3 ) with a record-breaking Se content (80 wt%) and high Se loading (8 mg cm -2 ) is demonstrated with a superhigh volumetric energy density up to 2502 Wh L -1 , surpassing that of LiCoO 2 .